反映物种：Human, Mouse, Rat

验证应用：WB, IHC-P, ELISA

同 种 型：IgG

推荐稀释比

WB：1:500 - 1:1000
IHC-P：1:50 - 1:200
ELISA：Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

免疫原

Recombinant protein (or fragment).This information is considered to be commercially sensitive.

理论分子量：63kDa

实际分子量：70kDa

产品形式：Liquid

偶联物：Unconjugated

阳性样本：HeLa, Rat thymus

细胞定位

Nucleus.

存储缓冲液

Store at -20℃. Avoid freeze / thaw cycles.
Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

纯化方式

Affinity purification

This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7.

基因ID：171017

Swiss Prot：Q8TF68